venofer dosing calculator

The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. commonly, these are generic drugs. Dosing: (a) Divide calculated total cumulate dose . Max Dose. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Applies only to oral form of both agents. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Pregnancy: Risk Summary-Clinical Considerations. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Use Caution/Monitor. Venofer has not been studied in patients younger than 2 years old. . Minor/Significance Unknown. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Last updated on Jun 1, 2022. Feraheme does not contain antimicrobial preservatives. This website is intended for use by US healthcare professionals only. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. You will have to pay for your IV iron. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Applies only to oral form of both agents. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Separate dosing of tetracyclines from these products. 1970;100(7):301303. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. . Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Schweiz Med Wochenschr. Minor/Significance Unknown. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Applies only to oral form of both agents. US residents can call their local poison control center at 1-800-222-1222. Ferritin and transferrin are also recommended monitoring . To view formulary information first create a list of plans. 2010;18(3). Applies only to oral form of both agents. If you log out, you will be required to enter your username and password the next time you visit. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Anemia; 2015: 763576. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Applies only to oral form of both agents. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Venofer treatment may be repeated if necessary. Assessing new treatment options. Use Caution/Monitor. Separate dosing of tetracyclines from these products. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. The primary endpoint was the proportion of patients with . Venofer must only be administered intravenously either by slow injection or by infusion. Applies only to oral form of both agents. Minor/Significance Unknown. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia ANNA J. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. It can be expressed in mg per ml. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Minor/Significance Unknown. STORAGE: Consult the product instructions and your pharmacist for storage details. Applies only to oral form of both agents. Slowing the infusion rate may alleviate symptoms. Venofer Injection Prescribing Information - Drugs.com iron sucrose, benazepril. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Accessed: 4/12/2011. Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. PDF Iron Sucrose: Guidelines for Administration Document Type: Guideline Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Accessed: 4/12/2011. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Iron Deficiency Calculator Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Intravenous iron sucrose: establishing a safe dose. Use Caution/Monitor. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Applies only to oral form of both agents. ]Venofer treatment may be repeated if iron deficiency reoccurs. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. 1) Ganzoni AM. Administer Venofer early during the dialysis session (generally within the first hour). Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. . 1. Monitor Closely (1)trientine, iron sucrose. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Minor/Significance Unknown. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Due Date form Ultrasound Report. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. 4. Test Dose: Not required. Use Caution/Monitor. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. https://www.uptodate.com/ (Requires subscription). IDA diagnosis is based on full blood examination and on the serum ferritin level. Do not mix iron sucrose with other medications or TPN solution. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Creating an account is free and takes less than 1 minute. Applies only to oral form of both agents. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Dose. Applies only to oral form of both agents. Applies only to oral form of both agents. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Avoid or Use Alternate Drug. Use Caution/Monitor. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Deferasirox chelates iron. Drug Dosing in Obesity Reference Table - ClinCalc.com Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Use Caution/Monitor. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Applies only to oral form of both agents. Volume of iron product required = 25 mL. Use Caution/Monitor. Venofer (iron sucrose) dose calculator | Calculosaurus.com IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Use Caution/Monitor. Applies only to oral form of both agents. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. 2.1 . Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). * Calculators are available in UpToDate to determine ideal body weight and lean body weight. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. No additional iron to replenish stores. This site complies with the HONcode standard for trust- worthy health information: verify here. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Applies only to oral form of both agents. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Dosage Calculator iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Venofer may cause clinically significant hypotension. Modify Therapy/Monitor Closely. Included in the iron dextran package insert. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Minor/Significance Unknown. Discard unused portion. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. Mean change in Hgb from baseline to Week 5 2,5 Interaction only with oral iron administration. Applies only to oral form of both agents. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Applies only to oral form of both agents. Copyright(c) 2023 First Databank, Inc. Applies only to oral form of both agents. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. If we don't have the calculator you need we'll try to make it for you and add it to the website. Applies only to oral form of both agents. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. . Iron Sucrose - SlideShare PDF Protocol for the use of Intravenous Iron Sucrose (Venofer iron sucrose increases levels of calcium citrate by enhancing GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. The dosage of Venofer is expressed in mg of elemental iron. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. Separate by at least 4 hours. Avoid or Use Alternate Drug. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Copyright 1993-2021 There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Methods. Although the original formula requires the weight in kilograms, values input in lbs are transformed. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Modify Therapy/Monitor Closely. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Separate dosing of tetracyclines from these products. 1. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. All Rights Reserved. Applies only to oral form of both agents. Applies only to oral form of both agents. PDF Venofer - Food and Drug Administration Applies only to oral form of both agents. Intravenous iron sucrose: establishing a safe dose - PubMed Use Caution/Monitor. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Applies only to oral form of both agents. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Avoid or Use Alternate Drug. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Applies only to oral form of both agents. This information does not assure that this product is safe, effective, or appropriate for you. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. 2012;2(4):288-335. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW Perinatology and Obstetrical Calculators Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Found in multiple references. Use Caution/Monitor. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. If either is present, do not use the liquid. Applies only to oral form of both agents. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Consult your pharmacist or local waste disposal company. commonly, these are "non-preferred" brand drugs or specialty Anemia caused by the depletion of iron is called iron deficiency anemia. Modify Therapy/Monitor Closely. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Use Caution/Monitor. Oral and parenteral products - see background option for oral products. and formulary information changes. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Modify Therapy/Monitor Closely. restrictions. Your doctor will do laboratory tests to monitor your response. Venofer treatment may be repeated if iron deficiency reoccurs. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 World J Gastroenterol; 16(22): 27202725. Applies only to oral form of both agents. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Iron deficiency anemia is the type of anemia caused by iron depletion. Human studies not conducted. Avoid or Use Alternate Drug. Kumpf VJ, Holland EG. Reference www.medicines.org.uk Background Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Use Caution/Monitor. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] ONE DOSE. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. gymnema decreases levels of iron sucrose by inhibition of GI absorption. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).]

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